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KMID : 0357119920140020231
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Korean Journal of Immunology
1992 Volume.14 No. 2 p.231 ~ p.246
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Effects of Monoclonal Anti-IL-4 Antibody(11B11) and Interferons on IgE Production In Vivo and Hypersensitivity Reactions Ⅱ. Suppressive Effects of a PAF Antagonist, BN 50739 on Active Systemic Anaphylaxis in Sensitized Mice
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하대유
이헌구/박형주/이황호/지용철/임선영
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Abstract
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Platelet activation factor (PAF) is a potent lipid mediator affecting various biological functions, including platelet activation, hypotention, brochoconstriction and immune functions, especially anaphylaxis. The discovery and development of PAF
receptor antagonists has greatly facilitated research in this field of PAF-mediated pathological effect of PAF. The purpose of the present study was to find out whether active systemic anaphylaxis (ASA) induced by protein antigen can be prevented
by a
novel PAF antagonist, BN 50739. The pretreatment of mice with PAF receptor antagonist alone or in the combination with cyclosporing A (CSA) before challenge with specific antigen protected mice from ASA, especially fatal ASA induced by
chicken-gamma
globulin (CGG) or ovalbumin (OVA). A novel PAF antagonist BN 50739 pretreatment protected mice from ASA induced by CGG ro OVA. The PAF antagonist BN 50739 pretreatment seemed to act in synergy with CSA in protection of mice from the fatal SAA.
OVA-specific IgE, IgG1 and IgG2a antibody responses in unprotected mice from OVA-induced fatal ASA were greater than those of suryived mice irrespective of PAF antagonist and/or CSA pretreatment of mice before challange. The present results
suggested
that PAF antagonist alone or in the combination of CSA may be useful in the prevention and treatment of inflammatory and allergic diseases in which PAF is assumed to be involved.
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KEYWORD
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